File Size: 1659 KB
Print Length: 288 pages
Publisher: Chelsea Green Publishing; 1 edition (January 25, 2017)
Publication Date: January 25, 2017
The writer utilizes a historical framework to make clear the science, and makes a strong advantages of cancer as a metabolic disease (as contrasted to a genetic one). Moreover, cures are to come from studies of metabolism, rather than from directly targeted treatments aimed as particular mutations.
Typically the treatment is historical, informing the story through the great researchers and their results, employing their stories to make clear the science. This makes the book very readable. Telling these stories is not necessary to learning the technology, but it may be necessary to understanding why, and when it was accepted.
Right after running through various historical figures, such as Warburg (who got his Nobel prize for demonstrating the metabolic abnormality of cancer), the story moves to various interesting modern statistics.
By page 93, he reaches the research in Pedersen's lab at John Hopkins University, and the story of the bright Korean biochemist, Youthful He Ko. She finds out that a simple chemical substance, 3-bromopyruvate, kills cancer tissue better and quicker than most chemotherapy drugs. She achieves the almost unprecedented feat of curing cancers in all of 19 rodents, who remain free of their original cancers to the conclusion of their natural life.
One would expect to learn how she got a professorship, fame, and plenty of research money. As an alternative, the academic politics at John Hopkins results in her being terminated, and a law suit, leaving the breakthrough unexploited. (Some assume that this provides the plot for a show, and think as to which celebrity should play Dr . Ko). For now, it just makes part of the book read like a book.
There is episode (starting on p. 109) when the father of a teenager near death from liver cancer listens to of the new medicine, and obtains approval for it to be administered in Germany (approved only because it was his only hope of evading his impending death). Typically the unemployed biochemist travels there, and waits nervously while the first human receives it. He was being held alive by tube nourishing. There are no serious aspect effects, and he requests to eat. The end result is that rather than not making it through to his 17th birthday as the doctor's forecasted, he recovers enough to go to John Hopkins Medical school to spiel, reaches his 18th birthday (a party that the still unemployed Dr. Ko attends). Alas, he eventually drops dead from an unrelated pneumonia, but the drug got achieved a "miraculous" treatment. Heart breaking drama here.
The story then moves on to the cutting advantage research on the inherited genes of cancer, and how when the genomes of varied growths were sequenced, there was found there was no pattern to the mutations, creating an embarrassment for those whose careers had already been in line with the genetic theory of cancer.
Naturally those who got dedicated their career to cancer as a innate disease were disappointed, and elaborate new theories, but several of the market leaders have shifted their focus to metabolism. Though it is straightforward to say the billions spend on genetic research was wasted, it was something that should have been done, and it appears we now know approaches that do not work.
As a subplot (p152) is the story of James Watson (whose Nobel prize was for discovering the innate code) and his move from emphasis on inherited genes (which naturally served his self interest), to attempts to get the Ko formulation, and him articulating support for the metabolic theory (when famous geneticists abandon the genetic theory, it is more convincing).
The story progresses to Dr. Seyfried (p. 167) and how he drifts into cancer research on discovering that starving rodents slowed tumor growth, and a drug that appeared effective against cancer actually seemed to work by stopping the mice from eating as much (the control mice not given the drug died much quicker, but control rodents restricted to eating only as much as the treated rodents chose to eat, did just as well).
This resulted in the syndication of a path busting book, The Metabolic Theory of Cancer. " While this is a very good book, and a must read for professional tumor researchers, the biochemistry is tough for non-professionals. With regard to laymen, one can to have understanding from "Tripping within the Truth" with much less work.
Even the professional may find that the historical narrative of this book makes it easier to understand Seyfried's book ( Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer ), with much less work, and without being lost in the details. Such reader's may wish to skip the initial two parts, which provide historical and scientific background).
Christofferson's book is less expensive, slightly more up to date (in a field that is moving fast, partially due to Seyfried's recent book), and more fun to read. After reading Christoffer's account of how Seyfried arrived to write his book, and exactly what he found, the professionals will be inspired to read the more specialized book written by the great scientist himself.
Dr . Seyfried explores ketones because the explanation for why calorie restriction works, and shows that a ketogenic diet can be effective (at least in mice). The story moves on to the history ketogenic diets, and a Florida researcher, D'gostino (p. 211), who becomes good results in rodents from such a diet plan, in particular when combined with hyperbaric oxygen therapy.
Small scale human tests of ketogenic diets for brain cancers begin (p. 196) and produce encouraging results.
Because so many reading this review will be those struggling from cancer, do you know the results for such patients Typically the first is the high potential of 3-bromopyruvate. Patients should not rush out there and try to get this and treat themselves. If incorrectly formulated, it could be fatal. Yet , they should keep their eyes open for studies (which are overdue, but practically certain to come). Individuals with advance, metastatic tumor need to be incorporated, even if this requires traveling overseas, and paying their own expenses.
The preliminary evidence is that a ketogenic diet is beneficial, and the book includes an appendix on "Putting Metabolic Therapy to Work". If I actually was dying from tumor, I might certainly try this.
Do you know the weak points in the book?
The first is that it does not have an index (so those thinking about a particular topic can find it). Also the chapter headings and table of contents are non-informative. This is why I described page numbers above.
While it has a list of sources in the back, it is not as well documented as a researcher would want. Fortunately, more are available in Seyfried's book.
It truly is clear from the sources he gives, that much of his information derives from traveling around the country interviewing the researchers themselves. This permits him to give the background that makes the book so readable (even novel like). A benefit for these interviews is that he sometimes describes results that have not yet been written up and published. This could be valuable to researchers and funders needing to understand what is heading on in a fast moving field.
Those thinking about the history and politics of science will enjoy the stories of the researchers, and how what should have been apparent leads and inconsistencies are not followed up on. That also becomes clear how problems of funding, individual egos and ambitions, and desire not to concede to having wasting time on exploring a blind alley (even though this may keep others from wasting time by heading down the same blind alley) has impeded research. Possible cures that are hard to earn money from such as 3-bromopyruvate (a known chemical that should not be patented) and nutritional methods are not as quickly followed up as those that can cause a highly profitable drug of marginal use (and he points just how marginal a lot of the hyped drugs are).
Those in funding positions (government, foundations, and those with money to donate) would benefit from reading this book and pondering about the implications. Drug companies naturally would like funding choices that lead to new drugs those to patent and market, and research that shows the utility of their products (and lobby for such). Yet , much higher earnings should derive from research private firms are unlikely to pursue, research on unpatentable molecules like 3-bromopyruvate, and nutritional therapies., Cancer: Is actually a terrifying diagnosis, often eventually resulting in one of two possibilities: either a prognosis that amounts to a death sentence, or, if more optimistic, a probability of "beating it, inches with the outlook of then spending more of one's life with back-of-the-mind worry that it will come back someday. Why have we made so little development in treating this illness? Why, over four years after President Nixon reported "war on cancer, inches do millions of people still experience the ravages of this disease and its toxic conventional treatments? When we set out to build an atomic bomb, there were the Manhattan Project, and accomplished it. When we decided we wanted to land a man on the moon, we threw money at the idea, and accomplished that, too. So why, after forty years, billions of dollars, and thousands of biochemists and researchers devoting their jobs to solving the insider secrets of cancer, have we made shamefully few inroads?
Is there a chance we've approached things from the incorrect angle? Is there a chance that we've mischaracterized the charge of cancer, and because of this, our treatments, medications, and prevention strategies are misguided and ineffectual? What if, all these years, cancer has got nearly all of us fooled, and all but a few brave and persistent experts have been so sidetracked by the *effects* of cancer that we've inadvertently ignored the underlying cause?
They are the questions Travis Christofferson explores in Slipping Over the Truth. In a book that covers tumor from its earliest acknowledgement centuries ago, to treatments and drug trials that are ongoing now, Christofferson makes a stunning situation suggesting that the reason our go-to treatments of surgery, radiation, and chemo ("slash, burn, and poison") so often fail to recover health and save lives is that they're focusing on the wrong thing. A person can't provide an efficient solution if you don't understand what the situation is. And a growing number of scientists believe we've been throwing options around about what amounts to either a guessing game or an ultra-high-stakes version of "whack-a-mole, " where as soon as one problem goes away, another pops up elsewhere. Nevertheless if we could find the root cause--the fundamental underlying injury in cancer--then we can attack it head-on and get eliminate it once and for all.
Christofferson details the variations between two competing theories of cancer etiology, with well-researched timelines covering the political, economic, social, and academic forces behind both. The one more widely-held right now is the "somatic mutation theory" (SMT). It posits that tumor is caused by changement to DNA. Carcinogenic elements cause errors in GENETICS replication, and also this results in tissue that misbehave--they gobble upwards fuel, they create their own blood supplies (angiogenesis), they poison nearby tissue, and they divide and multiply like crazy. They never die, like normal cells are programmed to do (apoptosis), and eventually, they spread from their site of origin and take root somewhere otherwise in the body (metastasis). This theory makes sense, because cancerous cells do have mutated DNA.
However, the competing theory--the metabolic theory--holds that mutated GENETICS is merely an *effect* of cancer, not the reason. This theory suggests that cancer is the outcome of an energy problem inside cells--specifically, the mitochondria have lost the ability to adequately perform "cellular respiration" and oxidative phosphorylation--making ATP. In other words, it's an energy technology problem. When mitochondria lose the ability to "respire" and create energy, they revert to fermentation instead, a primitive, highly bad survival mechanism that requires enormous amounts of glucose to power a cellular. One of the products of fermentation is lactate (lactic acid), which balances for the acidosis so common in cancer patients, and this is why alkalinizing therapies fail: people don't get cancer because their blood is acidic; their blood becomes acidic because the cancer cells produce a lot lactate. It's also why advanced cancer patients waste away (cachexia): the cancer cells "steal" glucose from the rest of the body, growing and spreading, while the rest of the body starves and shrinks.
Believe about it: When you don't have slept in quite some time, you haven't been eating right, and you're under stress, you make mistakes, right? You're tired, and you get sloppy and clumsy. Cells work the same way: when the mitochondria are damaged and cannot produce energy effectively, cells get sloppy. They make problems in DNA replication--so you observe the mutations here as consequences, not causes.
The actual crux of the metabolic theory is the glucose issue. Researchers have reputed for years that cancer tissue are "sugar junkies. inches They thrive on glucose, and because their mitochondria are either inadequate in number or are unable to start, they neglect to effectively metabolize fuel sources that healthy cells can use just fine: fatty acids and ketones. The mitochondria are so broken that even in the presence of oxygen, cancer cells must levain glucose--the "Warburg effect, inches and an unmistakable hallmark of most cancers.
Cancer cells' "Achilles' heel" is their reliance on glucose for survival. If the metabolic theory holds true, then targeting cancer cells not at the level of DNA, but at the level of metabolism, might hold the key to developing successful therapies. We all are still in the early stages of exploring this in the clinical setting (largely using ketogenic diets and hyperbaric oxygen), but Christofferson makes a powerful case for why these non-toxic treatments stand a much better chance of hitting tumor where it hurts than the chemo and rays, which often take people's lives faster and more completely than the cancer itself would have, if still left untreated. (Moreover, unlike chemo & radiation, metabolic treatments would *spare* healthy cells -- and in the truth of a ketogenic diet, by using *strengthen* it. In the very least, metabolic therapies prime the body to higher tolerate the severe effects of conventional treatment. )
Christofferson details the origins of the SMT, and then systematically dismantles its every tenet. With regard to each weakness in the SMT, the metabolic theory has a fascinating power. Pitted head-to-head, the metabolic theory fits the facts much more logically and scientifically. It's unfortunate that so much time, money, and research effort have been expended to hit those "whack-a-moles" one by one with the plastic hammer, when the answer all along might have already been simply to unplug the machine and cut off its power supply altogether.
Borrowing from the work of many scientists, Christofferson has written a book appropriate for medical professionals as well as laypeople thinking about this topic. The more scientifically minded might go on to tackle Dr . Thomas Seyfried's book, Cancer as a Metabolic Condition. But for individuals who just want to begin exploring these concepts, Tripping Over the Truth is a great introduction to the beauty and elegance of the metabolic origins theory, without the intimidating biochemistry and physiology. I applaud the writer for writing a book in regards to a complex scientific subject that reads like a novel. The prose is highly readable, and the descriptions of the players provide a good sense of who they are and what motivates them.
If the metabolic theory of cancer proves true, we will have these courageous scientists to thank, for persisting in their beliefs and holding fast to the notion that cancer is rather than an unsolvable riddle, but rather a biologically and evolutionarily conditioned reply to an energy crisis credited to mitochondrial insufficiency and dysfunction. And the best part of all: there are perfectly logical, *non-toxic* therapeutic avenues that can drive a stake right through cancer's heart.
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