eBook: Download Gene Intimate History Siddhartha Mukherjee ePub (KINDLE, PDF, MOBI) + Audio Version


  • File Size: 47543 KB
  • Print Length: 609 pages
  • Publisher: Scribner; Reprint edition (May 17, 2016)
  • Publication Date: May 17, 2016
  • Language: English

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Genes is humanity and lifestyle writ large, and this book on the gene by physician and article writer Siddhartha Mukherjee paints upon a canvas as big as life itself. It deals with both the great genetics and the applications in health plus disease. It shows us all that studying the gene not only holds the to transform the remedy of human disease plus to feed the planets burgeoning population, but promises to provide a windows into life’s deepest strategies and into our extremely identity as human beings.

The volume benefits from Mukherjee’s elegant literary style, novelist’s eye for character sketches and expansive feel for human history. Whilst there is ample explanation of the science, primary is really on the brilliant people who manufactured it all possible. The particular author’s own troubling family history of mental sickness serves as a background and keeps on parenting its head like a looming, unresolved question. The particular story begins using a journey to an asylum to see his troubled cousin; a pair of his uncles have also suffered from various " unravelings in the mind". This problem of personal inheritance sets the stage for numerous of the questions about nature, nurture and success asked in the webpages in this article.

The book can roughly be divided in to two parts. The very first part is a capturing and vivid history regarding genetics. The second 50 percent is a meditation upon what studying the gene means for human the field of biology and medicine.

The accounts much more or less date which approach naturally acts the historical portion well. Mukherjee does a commendable job shedding light upon the signal historical achievements of the men plus women who deciphered the secret of life. Stopping off from the Greeks’ nebulous but intriguing concepts on heredity, the book settles on the genes pioneer Gregor Mendel. Mendel was an abbot inside a little known town in Central Europe in whose pioneering experiments on pea plants provided the very first windows into the gene plus evolution. He discovered of which discrete traits could become transmitted in statistically expected ways in one generation to be able to next. Darwin came tantalizingly close to discovering Mendel’s ideas (the two had been contemporaries), but inheritance was one of the few things he got wrong. Instead, a triumvirate regarding scientists rediscovered Mendel’s function almost thirty years after his death and spread the word far and wide. Mendel’s work shows us all that genius can arise from probably the most unlikely quarters; one wonders how quickly his work might possess been disseminated had the net been around.

The baton in the gene was subsequent indexed by Francis Galton, Darwin’s cousin. Galton was the father of diathesis. Eugenics has now acquired a bad reputation, but Galton was a polymath who made important contributions to be able to science by introducing statistics and measurements in the study of genetic variations. Most of the early eugenicists subscribed for the racial theories of which were common in those days; many of them were well intended if patronizing, trying to ‘improve the weak’, but they did not see the ominous slick slope which they had been on. Sadly their concepts fed into the unlucky history of eugenics inside America and Europe. Diathesis was enthusiastically supported in the United States; Mukherjee discusses the famous Supreme Court case in which Oliver Wendell Holmes sanctioned the forced sterilization of your unfortunate woman named Carrie Buck by proclaiming, “Three generations of imbeciles usually are enough”. Another misuse regarding genetics was by Trofim Lysenko who tried to be able to use Lamarck’s theories regarding acquired characteristics in condemned agricultural campaigns in Stalinist Russia; as an ridiculous example, he tried to be able to “re educate” wheat using “shock therapy”. The terrible racial depredations in the Nazis which the narrative documents in some detail regarding course “put the greatest mark of shame” upon eugenics.

The book and then moves on to Jones Hunt Morgan’s very essential experiments on fruit flies. Morgan and his fellow workers found a potent tool to be able to study gene propagation inside naturally occurring mutations. Changement in specific genes (for instance ones causing changes in eye color) allowed these to track the flow regarding genetic material through several generations. Not only performed earning the crucial breakthrough that genes lie upon chromosomes, but they also discovered of which genes could be inherited (and also segregated) inside groups rather than by simply themselves. Mukherjee also offers an eye for historical detail; for example, proper at the time that Morgan was experimenting on flies, Russia was experimenting along with a bloody revolution. This particular coincidence gives Mukherjee a good opening to discuss hemophilia in the Russian royal family – a genetically inherited disease. A parallel discussion discusses the fusion regarding Darwin's and Mendel’s concepts by Ronald Fisher, Theodosius Dobzhansky and others in to a modern theory regarding genetics supported by record reasoning in the forties – what’s called the Modern Synthesis.

Morgan plus others’ work paved the way to recognizing that the gene is not merely some abstract, ether-like ghosting which transmits itself in to the next generation yet a material entity. Of which material entity was called DNA. The scientists most important for recognizing this truth were Frederick Griffiths plus Oswald Avery and Mukherjee tells their story well; however I would possess appreciated a fuller accounts of Friedrich Miescher who discovered DNA in pus bandages from soldiers. Griffiths showed that DNA can be accountable for converting non-virulent bacteria to virulent ones; Avery showed that it is a distinct molecule separate from protein (a large amount of people believed of which proteins with their functional significance were the genetic material).

Each one of these events set the stage for the golden age of molecular biology, the deciphering in the structure of DNA by simply James Watson (to whom the quote in the title is attributed), Francis Crick, Rosalind Franklin plus others. A number of these pioneers had been inspired with a little book by physicist Erwin Schrodinger which argued that the gene could be understood using precise principles regarding physics and chemistry; his arguments turned biology in to a reductionist science. Mukherjee’s accounts of this seminal breakthrough is crisp and brilliant. He documents Franklin’s challenges and unfair treatment as well as Watson plus Crick’s do-what-it-takes attitude to be able to use all possible info to crack the GENETICS puzzle. As a woman inside a man’s establishment Franklin is at turn patronized plus sidelined, but unlike Watson and Crick she was averse to building designs and applying the principles of chemistry to the problem, two traits of which were key to the duo’s success.

The construction of DNA of program inaugurated probably the most sparkling durations in the great intellectual thought since it instantly suggested an exact system for copying the genetic material as well as a link between GENETICS and proteins which usually are the workhorses of lifestyle. The major thread following from DNA to protein was the cracking in the genetic code which specifies a correspondence between nucleotides on a gene plus the proteins of a protein: the guiding philosophers in this effort had been Francis Crick and Sydney Brenner. A parallel thread follows the crucial function in the French biologists Francois Jacob and Jacques Monod - both of whom had fought in the French resistance during Globe War 2 - inside establishing the mechanism regarding gene regulation. Each one of these advancements laid the foundation for our modern era of genetic engineering.

The book devotes a great deal regarding space to this foundation and does so along with verve and authority. It talks about early attempts to sequence the gene at Harvard and Cambridge and describes the starting of Genentech, the very first company to exploit the brand new technology which pioneered numerous uses of genes for producing drugs and hormones: most of this important function was done with phages, viruses which infect germs. There is also an essential foray into using genes to understand embryology plus human development, a subject with ponderous implications for our future. With all the brand new technology also came brand new moral issues, as exemplified by the 1975 Asilomar conference which tried to be able to hammer out agreements for the responsible usage of genetic engineering. I am happy Mukherjee emphasizes these events, since their importance will undoubtedly grow as genetic technological innovation becomes more widespread plus accessible.

These early attempts exploded on to the stage when the Human Genome Project (HGP) was introduced, and that’s where the first part of the book roughly ends. Starting with the HGP, the second part mainly concentrates on the medical historical past and implications of the gene. Mukherjee’s discussion regarding the HGP focuses primarily on the rivalries between scientists and the rivalling efforts led by Francis Collins of the NIH and Craig Venter, the maverick scientist who out of cash off and started his own company. This discussion is somewhat brief yet it culminates in the announcement of the chart of the human genome at the White House in 2000. It will be clear now that this “map” was no more compared to a listing of elements; we still have to be able to understand what the elements mean. Part of of which lake of ignorance was revealed by the breakthrough of so-called ‘epigenetic’ components that modify not the basic sequence of GENETICS but the way it may be expressed. Epigenetics is a good up to now ill-understood mix regarding gene and environment which usually the book describes inside some detail. It’s well worth noting that Mukherjee’s discourse on epigenetics has faced several criticism lately, especially according to his article on the topic in the Fresh Yorker.

The book and then talks about early success in correlating genes along with illness that came with the advent of the human genome and epigenome; genes has been very helpful inside finding determinants and medicines for diseases like sickle cell anemia, childhood leukemia, cancer of the breast and cystic fibrosis. Mukherjee especially has a good excellent account of Nancy Wexler, the discoverer regarding the gene causing Huntington’s disease, whose look for the origins led her to be able to families stricken with the malady in remote areas of Venezuela. While such diseases possess clear genetic determinants, as Mukherjee expounds upon in length, genetic causes for diseases like cancer, diabetic and especially the mental illness which plagues members of the author’s family are woefully ill-understood, mainly as they are multifactorial and suffer from weakly correlated indicators. We have a considerable ways to be able to go before the majority of human diseases can be treated using gene-based treatment. In its second option half the book also describes attempts to link genes to homosexuality, contest, IQ, temperament and gender identity. The basic decision is that during your time on st. kitts will be undoubtedly a genetic part to all of these factors, the complex interplay between genes and environment means of which it’s very difficult presently to tease apart impacts from the two. A lot more research is clearly needed.

The particular last part of the book concentrates on some cutting edge analysis on genetics that’s unveiling both potent tools for precise gene engineering as well as deep insights into human evolution. A new notable section of the book is devoted to be able to the recent discovery of which Neanderthals and humans most likely interbred. Transgenic microorganisms, stem cells and gene therapy also get a healthy review, and the author talks about success and failures in these areas (an account regarding a gene therapy trial gone wrong is poignant and rattling) as well as ethical and personal questions which they boost. Finally, a new technological innovation called CRISPR which offers taken the world regarding science by storm becomes an honorary mention: by simply promising to edit and propagate genes with unprecedented accurate - even in the germ line - CRISPR has resurrected all the angels and demons from the history of genes. Whatever we decide about systems like CRISPR today may impact what our children do tomorrow. The time is ticking.

In a job as ambitious that presently there are bound to become a few gaps. Some of the gaps made me a bit befuddled though. There are a few minor scientific infelicities: for instance Linus Pauling’s construction of DNA was not really flawed because regarding a lack of magnesium (mg) ions but mainly because it sported a contact form of the phosphate groups that wouldn’t exist at the marginally alkaline pH in the human body. The book’s treatment of the genetic computer code leaves out some important exciting moments, such as when a scientific bombshell from biochemist Marshall Nirenberg disrupted a major conference in the former Soviet Union. I also held wondering how any discussion of DNA’s history may omit the famous Meselson-Stahl experiment; this experiment which usually very elegantly illuminated the central feature of GENETICS replication has been called “the most beautiful experiment in biology”. Similarly We could see no point out of Barbara McClintock in whose experiments on ‘jumping genes’ were critical in comprehending how genes can become turned on and away from. I was also surprised to find few details on a strategy called PCR without which modern genetic research can be virtually impossible: both PCR and the inventor Kary Mullis possess a colorful history that would have been worth which includes. Similarly, details of advanced sequencing techniques which possess outpaced Moore’s Law usually are also largely omitted. I understand that a 600 web page history cannot include every single single scientific detail, yet some of these omissions seem to me to be able to be too important to be able to be left out.

A lot more broadly, there is simply no discussion of the good qualities plus cons of using GENETICS to convict criminals: that would have made for a compelling human interest history. Nor is there a lot exploration of using gene sequences to illuminate the ‘tree of life’ which usually Darwin tantalizingly pulled the veil back on: inside general I might have valued a bigger discourse on exactly how DNA connects us to be able to all living creatures. There are likewise no accounts regarding some of the fascinating applications of DNA inside archaeological investigations. Finally, plus this is not his fault, the author suffers from the natural drawback of not being in a position to interview many regarding the pioneers of molecular biology since they aren’t around any more (fortunately, Horace Freeland Judson’s superb “The Eighth Day regarding Creation” fills this distance: Judson have to interview nearly every one of them for his book). This particular makes his account regarding science sound a little bit more linear than the messy, human process of which it is.

The quantity finishes by contemplating some philosophical questions: What are the moral and societal ramifications of being able to industrial engineer genomes in the embrionario stage? Exactly how control the evils where genetic technological innovation can be put? What exactly is natural and what isn’t in the age of the artificial gene? How do we balance the constant, almost inevitable pace regarding science with the human quest for responsible conduct, dignity and equality? Mukherjee results in us with a image of these questions as well as one regarding his as well as their contributed burden of mental sickness: a mirage trying to find understanding, a sea of concerns looking for a little boat filled up with answers.

Overall I found “The Gene: An Intimate History” to become beautifully written with a literary flair, and inside spite in the omissions, the parts of genetic historical past and medicine which it can discuss are important plus instructive. Its human stories are poignant, its lessons for future years pregnant with issues and possibilities. Its capturing profile of life’s innermost secrets could not aid but remind me of a Japan proverb quoted by physicist Richard Feynman: “To every single man has the important to the gates regarding heaven. The same important opens the gates regarding hell. ” The gene may be the ultimate key regarding this kind, and Mukherjee’s book explores its fine contours in most their glory and tragedy. We possess a choice in deciding which of these curves you want to follow., Gene will be a must-read history book on genetics. Many company accounts have been penned upon Relativity and Quantum Technicians, for instance, to help to make their importance known to be able to the non-professionals. Gene fills the void for the equally important science regarding Genetics.

The author's biggest success is in weaving an attractive narrative. Starting along with the emotionally-charged personal backlinks to the field to be able to the frequent detailing regarding personalities of or stories involving famous scientists, this issue is kept 'human'. There are abundant scientific notions to meet any reader picking up the book to realize the real subject material, yet not in the basic bland fashion of studies-and-conclusions that tend to drop many a lay people.

The book also does a great job because of the simplicity with which countless unique concepts are explained. Coming from the notions of introns and exons to the polygenic nature of most phenotypes, the feedback from surroundings to gene mutation plus the massive role performed by non-gene factors in many our traits, the author uncovers a staggering amount of interesting findings inside a highly understandable way.

Amid all this, the author keeps the emphasis on various moral and ethical concerns. The narrative is laced with historic episodes regarding all kinds to stress the criticality of the questions confronting us as we make more technological progress. For example, the book beautifully explains the dangers of genetic changes - which tantamounts to be able to replacing natural selection along with human selection. As professionals or parents seek to be able to weed out certain deformities, there are genuine risks individuals eliminating some essential evolutionary traits mainly away of ignorance of exactly how genes really work at this point but also out regarding their possible other utilities in long future.

The particular biggest flaw of the book is insufficient emphasis on latest developments plus near absence of what this science has the ability to of solving in coming decades. The particular optimists out there expect congenitally blind individuals to see plus cancers all cured. Some expect us to become able to grow a third arm if we so choose or re-create a dinosaur inside a millennium or so. Genetics will be combined with nanotechnology, cryonics, robotics etc by numerous fantasizers to generate even more fanciful theories. The writer may have added a part or two to discuss gene therapy and other recent experiments to finish the excellent work further.

Having said that, a remarkable book inside all aspects.

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Gene Intimate History Siddhartha Mukherjee
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